Innovation in the areas of donor management and organ preservation offers the most realistic hope to improve both the quality and size of the current organ supply although the basic science dissecting the complex processes of brain death and ischemia/reperfusion injury is replete with exciting discoveries, the clinical science investigating donor management and organ preservation is sparse in contrast. The object of this review is to describe current strategies and generate insight into new and promising strategies for novel solutions designed to optimize donor heart preservation improved preservation could lead to more time for immunologic matching of the donor with potential recipients. Preservation solutions for cardiac and pulmonary donor grafts: a review of the current literature hypothermic preservation of donor grafts is imperative to ameliorate ischemia related cellular damage prior to organ transplantation. One of the major limitations in heart transplantation has been the preservation of the donor heart currently used preservation solutions offer only up to 4 hours of safe storage because heart transplantation survival is inversely correlated with cold ischemic time, 1 an improvement in the quality of preservation would influence acute survival.
The use of organs from marginal donors, such as the non heart-beating donor (nhbd), has become an important means for expansion of the donor organ pool for these organs, the preservation method applied is of even greater importance than for heart-beating donor organs. Cel was initially a favorable extracellular preservation solution for heart transplants with several studies supporting its use a prospective study containing 70 patients revealed a safe role for cel as a preservation solution in the setting of heart transplants with a 30-day survival of 914% and acute graft failure rate of 10%. The effect of metabolic inhibitor, hypothermia (4°c) and hyperbaric oxygenation (3 atm) on prolonging survival of the canine anoxic heart has been evaluated donor hearts were obtained from small mongrel dogs by giving the pre-cooled perfusate of 2 per cent magnesium sulfate (mgso 4 ), 5 per cent low molecular weight dextran (lmwd) and 2 per cent glucose into the right atrium.
A prospective study containing 70 patients revealed a safe role for cel as a preservation solution in the setting of heart transplants with a 30-day survival of 914% and acute graft failure rate of 10%. The purpose of this study was to assess the potential of using the ctl approach in an ischemically damaged heart as a marginal donor in rat heart transplantation methods experimental design male lewis rats, weighing 150 to 250 mg, were used as donors and recipients in this study.
Cardioplegia (cbc) in donor heart preservation methods sixty-seven patients undergoing heart transplantation in tri-service general hospital, taipei, taiwan between 2002 and 2012 were enrolled in this study patients were divided into an htk group and a cbc group based on the preservation solution used to protect the donated hearts. Herein we present our clinical experiences and patient outcomes using this technique for donor heart protection methods this retrospective analysis of a nonrandomized study included 51 hts performed at our institute from june 2008 to march 2010 twenty donor hearts preserved with st thomas cardioplegia solution only were excluded from this study. Currently, heart preservation is limited to 4 to 6 hours of cold ischemic storage, and the effectiveness depends to a great extent on the solution and its temperature. Pothermic static preservation became the standard method for cardiac preservation in the following paragraphs we will high-light the key issues and clinical results about cardiac preservation as published in recent literature, furthermore discuss consequences resulting from recent changes in profiles of donor and heart transplant recipients.
Prolonged donor heart preservation with pinacidil: the role of mitochondria and the mitochondrial adenosine triphosphate-sensitive potassium channel. - organ donation organ donation is a topic which contains many conflicting views to some of the public population organ donation is a genuine way of saving the life of another, to some it is mistrusted and to others it is not fully understood.
Donor heart preservation with the potassium channel opener pinacidil: comparison with university of wisconsin and st thomas’ solution however, pin was inferior to uw as a form of donor-heart protection the role of pin in future myocardial protection strategies will require further investigation. Request pdf on researchgate | heart preservation for transplantation: principles and strategies | while transplantation is a proven modality for the treatment of end stage organ disease, an. While transplantation is a proven modality for the treatment of end stage organ disease, an important determinant of outcome is the adequacy of organ preservation.
While transplantation is a proven modality for the treatment of end stage organ disease, an important determinant of outcome is the adequacy of organ preservation currently, heart preservation is limited to 4 to 6 hours of cold ischemic storage, and the effectiveness depends to a great extent on the solution and its temperature.